RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppresses the activation of antigen-specific T cells and B cells, and can ameliorate pulmonary inflammation and lupus nephritis.
Molecular Weight:
614.56
CAS Number:
[1252637-46-9]
Formula:
C27H24F6N4O4S
Target:
Others|||Cysteine Protease
T73220
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