APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellular accumulation of platinum and initiates the activation of DNA damage response and apoptosis pathways [1].
Molecular Weight:
522.21
CAS Number:
[2923433-95-6]
Formula:
C9H12Cl2N4O5Pt
Target:
MDM-2/p53|||Apoptosis
T73299
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