DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK).DN-1289 significantly inhibited optic nerve crush (ONC)-induced p-c-Jun in a mouse model.
Molecular Weight:
441.38
Purity:
>99.99%
Formula:
C18H19F4N7O2
Target:
DNA Alkylation|||JNK
T73457
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