ADH-6, a tripyridylamide compound, impedes the self-assembly of the aggregation-nucleating subdomain of mutant p53 DNA-binding domain (DBD). By targeting and dissociating mutant p53 aggregates in human cancer cells, ADH-6 reinstates p53s transcriptional activity, culminating in cell cycle arrest and apoptosis, thereby holding potential for cancer research.
Molecular Weight:
640.64
CAS Number:
[2227429-65-2]
Formula:
C29H36N8O9
Target:
Others|||Apoptosis|||MDM-2/p53
T73533
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