PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies, exhibiting potent activity with DC50 values of 0.23 nM and 0.38 nM for the respective conjugations [1].
Molecular Weight:
1292.56
Formula:
C61H75F2N9O12S4
Target:
Others|||PROTACs|||PROTAC-Linker Conjugates for PAC|||Epigenetic Reader Domain
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