MS143, a potent AKT degrader (DC50=46 nM and GI50=0.8 µM in PC3 cells), effectively induces AKT degradation through the ubiquitin-proteasome system in both a concentration- and time-dependent manner, leading to the suppression of cancer cell growth [1].
Molecular Weight:
1121.87
CAS Number:
[2376137-41-4]
Formula:
C59H81ClN12O6S
Target:
Akt|||PROTACs|||Others
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