YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhibitor 48 (compound 6d) as the ligand, YF135 utilizes the MRTX849 linkage VHL ligand scaffold.
Molecular Weight:
1179.86
CAS Number:
[2913177-53-2]
Formula:
C63H75ClN12O7S
Target:
ERK|||Ras|||PROTACs|||Kras
T74336
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