JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC). It serves as a potent HDAC1/2 degrader, resulting in a significant increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Molecular Weight:
898.12
CAS Number:
[2669785-77-5]
Formula:
C48H63N7O8S
Target:
PROTACs|||Others|||HDAC
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