JPS035, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), specifically HDAC1/2. Its potent activity is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Molecular Weight:
896.15
CAS Number:
[2669785-84-4]
Formula:
C49H65N7O7S
Target:
PROTACs|||Others|||HDAC
T74455
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