MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1].
Molecular Weight:
993.47
CAS Number:
[2772613-37-1]
Formula:
C48H58ClFN8O12
Target:
Others|||PROTACs|||EGFR
T74633
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