JNJ-28583113 is a brain-penetrant TRPM2 antagonist that induces phosphorylation of GSK3alpha and beta subunits, protecting cells from oxidative stress-induced cell death. It inhibits microglia response to pro-inflammatory stimuli, used in the study of neurological diseases.
Molecular Weight:
366.38
Purity:
98.57%
CAS Number:
[2765255-93-2]
Formula:
C19H21F3N2O2
Target:
TRP/TRPV Channel
T74779
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