PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS production and modulates apoptotic proteins, engaging in both mitochondrial and death receptor pathways [1].
Molecular Weight:
697.92
Formula:
C36H43NO7S3
Target:
PDK|||Others|||Apoptosis|||Akt|||EGFR|||PKM
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