TD1092, a pan-IAP degrader, effectively degrades cIAP1, cIAP2, and XIAP, catalyzing the activation of Caspase 3/7 and fostering apoptosis in cancer cells through IAP degradation. It also obstructs the TNFalpha-mediated NF-kappaB pathway, diminishing the phosphorylation of IKK, IkBalpha, p65, and p38, and operates as a PROTAC. This compound is utilized in cancer research [1].
Molecular Weight:
987.19
Formula:
C55H70N8O9
Target:
Others|||IAP|||PROTACs|||Caspase
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