RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models [1].
Molecular Weight:
1012.26
Purity:
99.92%
CAS Number:
[2641998-63-0]
Formula:
C55H78FN9O8
Target:
Kras|||Ras|||Apoptosis|||ERK
T75131
T75131
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