PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 µM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Molecular Weight:
237.32
Purity:
98.00%
CAS Number:
[4079-26-9]
Formula:
C15H11NS
Target:
Autophagy|||Lipoxygenase|||Ferroptosis
T7530
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