()-Evodiamine is an alkaloid isolated from Evodiae fructus and a topoisomerase I inhibitor. It also inhibits adipocyte differentiation and diabetes by downregulating IGF-1/HIF-1alpha and IL-6/STAT pathways. As an inhibitor of NF-kappaB activation, it suppresses invasion, promotes apoptosis, and inhibits TNF-induced Akt activation.
