K41498 TFA, an analog of antisauvagine-30 (aSvg-30), is a potent and highly selective antagonist of CRF2 receptors, exhibiting K i values of 0.66 nM, 0.62 nM, and 425 nM for human CRF 2alpha, CRF 2beta, and CRF 1 receptors, respectively. This compound effectively inhibits sauvagine-stimulated cAMP accumulation in cells expressing hCRF 2alpha and hCRF 2beta. It is utilized in studies investigating hypotension [1].
Molecular Weight:
3746.22
Formula:
C164H277F3N48O48
Target:
CFTR
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