PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the alpha7 subunit of the proteasome, preventing the degradation of the NF-kappaB inhibitor IkappaBalpha through the ubiquitin-proteasome pathway. Additionally, PR-39 TFA promotes angiogenesis, suppresses inflammatory responses, and notably decreases myocardial infarct size in mice [1] [2].
Molecular Weight:
4833.76
Formula:
C231H347F3N70O42
Target:
Proteasome|||Antibacterial
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