Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface receptors and activating inflammatory signaling. Emapalumab has a high binding force (Kd=1.4 pM) to free IFN-gamma and to IFN-gamma bound to its receptor. Emapalumab can be used in the study of hemophagocytic lymphohistiocytosis (HLH).
Purity:
95.00%
CAS Number:
[1709815-23-5]
Target:
COX|||IFNAR
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