GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3alpha and GSK-3beta with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau protein S396 with an IC50 of 10 nM in a triple transgenic mouse model of Alzheimers disease. GSK-3 inhibitor 3 reduced the phosphorylation level of tau protein S396 in a triple transgenic mouse model of Alzheimers disease, with an IC50 of 10 nM.GSK-3 inhibitor 3 can be used for the study of neurological diseases.
Molecular Weight:
410.4
Purity:
99.89%
CAS Number:
[2227279-84-5]
Formula:
C23H15FN6O
Target:
GSK-3|||Microtubule Associated
T77342
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