BML-278 is a SIRT1 activator with an EC150 of 1 µM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.
Molecular Weight:
391.46
Purity:
>99.99%
CAS Number:
[120533-76-8]
Formula:
C24H25NO4
Target:
Histone Methyltransferase|||Sirtuin
* VAT and and shipping costs not included. Errors and price changes excepted
