Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.
Molecular Weight:
1037.33
Purity:
99.02%
CAS Number:
[1912408-92-4]
Formula:
C55H88N8O11
Target:
Drug-Linker Conjugates for ADC|||Microtubule Associated
T77883
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