SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It effectively suppresses cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis, demonstrating superior properties compared to Brigatinib [1].
Molecular Weight:
919.79
Formula:
C43H49Cl2N10O7P
Target:
PROTACs|||Apoptosis|||EGFR|||ALK
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