Dimethylamiloride hydrochloride selectively inhibits Na/H exchangers located in cellular membranes, leading to intracellular H retention and a reduction in intracellular pH, Dimethylamiloride hydrochloride additionally blocks TRPA1 ion channels with an IC50 of 80 µM, making it a valuable pharmacological tool for studying ion transport, pH homeostasis, sensory signaling, and inflammatory pain mechanisms.
Molecular Weight:
257.68
Purity:
98.90%
CAS Number:
[1214-79-5]
Formula:
C8H12ClN7O
Target:
Sodium Channel
T78139
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