Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable CSF1-R inhibitor with an IC50 of 1 nM, promoting apoptosis in tumor cells and significantly restricting tumor growth in murine models, thereby proving useful in cancer and amyotrophic lateral sclerosis (ALS) studies [1].
Molecular Weight:
471.4
CAS Number:
[2222138-40-9]
Formula:
C20H24Cl2N4O3S
Target:
c-Fms
T78603
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