LY393615 (NCC1048) is a novel blocker of both neuronal Ca (calcium) and Na (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC50) of 1.9 µM and 5.2 µM against alpha1A and alpha1B calcium channel subunits, respectively. This compound demonstrates effective brain penetration and has shown neuroprotective effects in cerebral ischemia models, suggesting its utility in neurological disease research [1].
Target:
Calcium Channel|||Sodium Channel
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