2-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzymes active site [1].
Molecular Weight:
283.31
CAS Number:
[136904-69-3]
Formula:
C10H13N5O3S
Target:
EGFR
T78634
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