MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, with dissociation constants (Kis) of 0.23 µM for MDM2 and 2.45 µM for MDMX. It disrupts the interaction between p53 and MDM2 proteins, reinstating p53 functionality to induce cell cycle arrest and apoptosis. Additionally, this compound impedes cell migration and invasion, exhibiting notable antitumor activity [1].
Molecular Weight:
576.87
Formula:
C28H25Cl3FN3O3
Target:
Apoptosis|||Others|||MDM-2/p53
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