Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a pi-cationic interaction with Lys352 of Tubulin and demonstrating high efficacy against SNB-19, OVCAR-8, and NCI-H460 with PGIs of 86.61, 85.26, and 75.99, respectively. Moreover, it shows moderate activity against a range of other cancer cell lines - HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 - with PGIs between 51.88 and 67.55 [1].
Molecular Weight:
319.28
Formula:
C16H12F3N3O
Target:
Microtubule Associated|||Others
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