Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 µM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 µM in MCF-7, 1.7 µM in HeLa, 2.4 µM in BGC-823, 2.8 µM in SW-480, and 2.1 µM in A549 cells. Additionally, TrxR1-IN-1 possesses antioxidant activity, effectively scavenging the DPPH radical [1].
Molecular Weight:
465.36
Formula:
C23H18N2O4Se
Target:
Others
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