PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].
Molecular Weight:
610.41
Formula:
C25H23IN8O3
Target:
Apoptosis|||PARP|||CDK
* VAT and and shipping costs not included. Errors and price changes excepted
