PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule from the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antagonizing AR-NTD, it effectively degrades AR-V7 protein and induces apoptosis in prostate cancer (PC) cells, with degradation efficiencies of 62.2% (1 µM) and 71.1% (5 µM) in VCaP cells [1].
Molecular Weight:
771.3
Formula:
C41H47ClN6O7
Target:
Apoptosis|||Androgen Receptor
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