JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1beta, IL-1alpha, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice [1].
Molecular Weight:
432.49
CAS Number:
[2238820-43-2]
Formula:
C20H24N4O5S
Target:
NOD-like Receptor (NLR)
T78822
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