H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRNs helicase function through competitive ATP antagonism [1].
Molecular Weight:
548.46
CAS Number:
[2912294-90-5]
Formula:
C22H18F6N4O4S
Target:
DNA/RNA Synthesis
T78938
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