Antiproliferative agent-30 (Compound 8g) exhibits broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It inhibits tubulin assembly, FLT3, and Abl1 kinases and shows vascular-disrupting capabilities. Additionally, it displays an anticancer effect against acute myeloid leukemia (AML) with FLT3-ITD-TKD mutations [1].
Molecular Weight:
434.49
CAS Number:
[2713553-88-7]
Formula:
C24H26N4O4
Target:
Microtubule Associated|||FLT|||Others|||Bcr-Abl
T79322
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