Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), enhances endoplasmic reticulum (ER) stress, and upregulates activating transcription factor 3 (ATF3) expression, demonstrating potent anti-liver cancer effects both in vitro and in vivo [1].
Molecular Weight:
578.58
CAS Number:
[2241283-11-2]
Formula:
C32H40BrN3O2
Target:
Ferroptosis
T79359
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