Antiproliferative agent-34, CAS [[2910858-34-1]]

Product Overview

• Article Name: Antiproliferative agent-34, CAS [[2910858-34-1]]
• Biozol Catalog Number: TGM-T79368
• Supplier Catalog Number: T79368
• Alternative Catalog Number: TGM-T79368-25MG,TGM-T79368-50MG,TGM-T79368-100MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT. Additionally, it inhibits JAK2, ROS1, FLT3, FLT4, and PDGFRalpha with respective IC50s of 30.93 nM, 106.90 nM, 108.00 nM, 226.60 nM, and 42.53 nM. In normoxic conditions, it suppresses the proliferation of H1975 and HCC827 cells with IC50 values below 40 nM, while under hypoxic conditions, its potency increases 4-6 fold, yielding IC50 values less than 10 nM [1].

Product Properties

• Molecular Weight: 529.55
• CAS Number: [2910858-34-1]
• Formula: C27H27N7O5
• Target: EGFR

Images

T79368