ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK/EGFR mutants with IC50 values of 4.3 nM for EGFR L858R T790M in H1975 cells and 3.6 nM for EML4-ALK in BaF3 cells. This compound may be applicable in the research of non-small cell lung cancer (NSCLC) [1].
Molecular Weight:
572.12
CAS Number:
[2730430-08-5]
Formula:
C27H34ClN7O3S
Target:
ALK|||EGFR|||Apoptosis
T79392
* VAT and and shipping costs not included. Errors and price changes excepted
