SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 µM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (OCR), increasing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP). Furthermore, SCAL-266 demonstrates significant antiproliferative activity against OXPHOS-dependent cancer cells [1].
Molecular Weight:
511.54
CAS Number:
[2798953-78-1]
Formula:
C27H28F3N5O2
Target:
Mitochondrial Metabolism|||OXPHOS
T79477
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