MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 µM for MAO A and 4.58 µM for HSP90. This compound enhances HSP70 expression, diminishes HER2 and phospho-Akt levels, downregulates IFN-gamma-induced PD-L1 expression in GL26 cells, and demonstrates efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, and non-small cell lung cancer, possibly impeding tumor immune evasion [1].
Molecular Weight:
458.98
CAS Number:
[2927489-99-2]
Formula:
C25H31ClN2O4
Target:
HSP|||Monoamine Oxidase
T79487
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