22-(4'-py)-JA, CAS [[1178895-15-2]] Preis auf Anfrage

Product Overview

• Article Name: 22-(4'-py)-JA, CAS [[1178895-15-2]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T79560
• Supplier Catalog Number: T79560
• Alternative Catalog Number: TGM-T79560-5MG,TGM-T79560-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: 22-(4'-Pyridinecarbonyl) jorunnamycin A

Product Description

22-(4'-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF). Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].

Product Properties

• Molecular Weight: 598.6
• CAS Number: [1178895-15-2]
• Formula: C32H30N4O8
• Target: Akt|||mTOR

Images

T79560