Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-kappaB pathway and reducing the expression of iNOS, TNF-alpha, IL-6, and IL-1beta. It notably suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 0.8 µM and demonstrates anti-inflammatory effects in vivo using a mouse auricular edema model [1].
Molecular Weight:
373.32
CAS Number:
[2924156-51-2]
Formula:
C17H15N3O7
Target:
NO Synthase|||TNF|||Interleukin|||Others|||NF-kappaB
T79620
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