Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].
Molecular Weight:
421.66
CAS Number:
[444914-19-6]
Formula:
C26H47NO3
Target:
MDM-2/p53|||Ferroptosis|||Glutathione Peroxidase
T79638
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