EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, with IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It induces apoptosis and S phase cell cycle arrest in MCF-7 cells, showing significant anti-cancer activity with an IC50 of 2.74 µM against MCF-7 cells [1].
Molecular Weight:
468.55
Formula:
C24H16N6OS2
Target:
EGFR|||CDK
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