NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1beta secretion. It possesses excellent pharmacokinetic properties and has shown significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis [1].
Molecular Weight:
413.53
CAS Number:
[2428478-22-0]
Formula:
C22H27N3O3S
Target:
NOD-like Receptor (NLR)
T79733
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