SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanotransduction, with both histamine-dependent and independent pathways reported. While PAR-3 alone does not induce itch, it may potentiate itch when co-expressed with PAR-4, enhancing thrombins action. This suggests that PAR-3s primary function is not as a signal transmitter across the membrane, but rather as a cofactor necessary for PAR-4 activation.
Molecular Weight:
576.6
CAS Number:
[261521-21-5]
Formula:
C25H36N8O8
Target:
Protease-activated Receptor
T80234
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