Epsilon-V1-2, a Cys-conjugated, is a biologically active peptide known as the epsilonPKC-specific inhibitor. It hampers epsilonPKC functionality by obstructing its translocation and the phosphorylation of MARCKS, additionally perturbing epsilonPKCs interaction with its anchoring protein, epsilonRACK. The peptide includes a cysteine residue at its C-terminus, facilitating the formation of potential disulfide bonds with carrier proteins. Pyroglutamyl formation can occur spontaneously at the N-terminus if glutamine or glutamic acid is present, enhancing peptide stability against gastrointestinal proteases. Pyroglutamyl peptides, a recognized subset, are accounted for in the peptides purity during HPLC analysis.
Molecular Weight:
947.11
Formula:
C40H70N10O14S
Target:
PKC
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