Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for immune responses. It disrupts the interaction between the betagamma subunit of the Gi protein and downstream effectors linked to the fMLP receptor, thus abrogating fMLP-induced respiratory bursts. Additionally, larixol effectively reduces fMLP (0.1 µM)-triggered superoxide anion generation (IC50: 1.98 µM), cathepsin G secretion (IC50: 2.76 µM), and cellular chemotaxis, mitigating neutrophil hyperactivation and subsequent inflammation or tissue injury. Derivatives of larixol also demonstrate inhibitory activity on TRPC6 functional mutants associated with FSGS [1] [2].
Molecular Weight:
306.48
CAS Number:
[1438-66-0]
Formula:
C20H34O2
Target:
Akt|||ERK|||Src
T80653
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