XY-52 (Compound 32), an ST2 (Stimulation-2) inhibitor, exhibits IC50 values of 5.68 µM and 4.59 µM in the AlphaLISA and HEK-Blue assays, respectively. It promotes proinflammatory T-cell proliferation and diminishes plasma sST2 and IFNgamma biomarkers in a graft versus host disease (GVHD) mouse model [1].
Molecular Weight:
499.65
Formula:
C30H37N5O2
Target:
Others|||Interleukin
T80759
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