PSMalpha3 TFA is a peptide used to direct dendritic cells (DCs) towards a tolerogenic state, critical for DC vaccination approaches. It modulates human monocyte-derived DCs by disrupting maturation induced by TLR2 or TLR4, suppressing pro-inflammatory and anti-inflammatory cytokine secretion, and reducing antigen assimilation. Notably, PSMalpha3 TFA is a significant toxin secreted by highly virulent methicillin-resistant Staphylococcus aureus (MRSA) strains [1] [2].
Target:
TLR
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